#  Could Recreating a Rare Mutation Grant Almost Universal Virus Immunity For Days?
robot (spnet, 1) → All  –  03:22:01 2025-08-25

"For a few dozen people in the world, the downside of living with a rare immune condition comes with a surprising superpower — the ability to fight off all viruses..." notes an announcement from Columbia University.

"At first, the condition only seemed to increase vulnerability to some bacterial infections. But as more patients were identified, its unexpected antiviral benefits became apparent."

Columbia immunologist Dusan Bogunovic discovered the individuals' antiviral powers about 15 years ago, soon after he identified the genetic mutation that causes the condition... Bogunovic, a professor of pediatric immunology at Columbia University's Vagelos College of Physicians and Surgeons, soon learned that everyone with the mutation, which causes a deficiency in an immune regulator called ISG15, has mild, but persistent systemic inflammation... "In the back of my mind, I kept thinking that if we could produce this type of light immune activation in other people, we could protect them from just about any virus," Bogunovic says.

Today, Bogunovic is closing in on a therapeutic strategy that could provide that broad-spectrum protection against viruses and become an important weapon in next pandemic. In his latest study, published August 13 in Science Translational Medicine, Bogunovic and his team report that an experimental therapy they've developed temporarily gives recipients (hamsters and mice, so far) the same antiviral superpower as people with ISG15 deficiency. When administered prophylactically into the animals' lungs via a nasal drip, the therapy prevented viral replication of influenza and SARS-CoV-2 viruses and lessened disease severity. In cell culture, "we have yet to find a virus that can break through the therapy's defenses," Bogunovic says...

Bogunovic's therapeutic turns on production of 10 proteins that are primarily responsible for the broad antiviral protection. The current design resembles COVID mRNA vaccines but with a twist: Ten mRNAs encoding the 10 proteins are packaged inside a lipid nanoparticle. Once the nanoparticles are absorbed by the recipient's cells, the cells generate the ten host proteins to produce the antiviral protection. "We only generate a small amount of these ten proteins, for a very short time, and that leads to much less inflammation than what we see in ISG15-deficient individuals," Bogunovic says. "But that inflammation is enough to prevent antiviral diseases...."

"We believe the technology will work even if we don't know the identity of the virus," Bogunovic says. Importantly, the antiviral protection provided by the technology will not prevent people from developing their own immunological memory to the virus for longer-term protection.

"Our findings reinforce the power of research driven by curiosity without preconceived notions," Bogunovic says in the announcement. "We were not looking for an antiviral when we began studying our rare patients, but the studies have inspired the potential development of a universal antiviral for everyone."

More coverage from ScienceAlert.

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#  Burning Man Hit By 50 MPH Dust Storm. Possible Monsoon Thunderstorms Forecast
robot (spnet, 1) → All  –  01:22:02 2025-08-25

"A fierce dust storm hit the Black Rock Desert on the eve of its annual Burning Man festival," reports the San Francisco Chronicle, "causing at least four minor injuries and damaging campsites that had been set up early." [Alternate URL]

"Winds of up to 50 mph stirred up the lake bed's alkaline dust so ferociously that participants in the annual art and culture festival reported not being able to see beyond a foot... "

The dust storm arrived Saturday evening after strong thunderstorms in the Sierra Nevada drifted off the mountains and whipped up strong winds in the Nevada desert... At 5:14 p.m. Saturday, the weather service issued a dust storm advisory for Black Rock City and warned of "a wall of blowing dust coming off the Smoke Creek and Black Rock Desert playa areas is tracking northward at around 30 mph." The agency warned of visibility less than 1 mile and wind gusts exceeding 45 mph. A weather station at Black Rock City Airport measured gusts up to 52 mph at 5:50 p.m... ["We saw structures being ripped and torn down by the wind speeds even though we buttoned everything down as best as we could..." one Burner told the Chronicle.] Camp residents posted a slew of videos to social media featuring dust tornadoes, destroyed campsites, and fellow campers struggling to hold onto bucking canvases as the wind threatened to rip them away. "Every popup canopy I've seen has been destroyed," one Burner wrote on Reddit... ["Make sure you carry your particle/dust mask and goggles with you when you venture out on playa!" warns Burning Man's official weather page.]

Even after Saturday's storm, Burners won't be out of the woods from hazardous weather. The weather service warned of possible monsoon thunderstorms and heavy rain Sunday through Wednesday, raising concerns that this year's festival could echo disastrous 2023 conditions, when heavy storms stranded tens of thousands of attendees amid thick mud. "It's becoming increasingly likely that we could see an even greater flash flood threat," the weather service wrote in an online forecast. "If you're on the playa at the Black Rock Desert, you may very well be in for a muddy mess Monday through Wednesday." Slow-moving storms could drop an inch of rain or more in a short period.

"Still, gates to the festival had opened by Sunday morning," the article adds, "with organizers cautioning new arrivals to 'drive safely!'"

Burning Man's official weather page currently links to a National Weather Service page with a "Flood Watch" warning through 9 p.m. Sunday, and also predicting a chance of thunderstorms on Sunday and Monday.

[ Read more of this story ]( https://news.slashdot.org/story/25/08/25/0027216/burning-man-hit-by-50-mph-dust-storm-possible-monsoon-thunderstorms-forecast?utm_source=atom1.0moreanon&utm_medium=feed ) at Slashdot.
#  After Tea Leak, 33,000 Women's Addresses Were Purportedly Mapped on Google Maps
robot (spnet, 1) → All  –  23:22:01 2025-08-24

After the Tea dating-advice app leaked information on its users, the BBC found two online maps "purporting to represent the locations of women who had signed up for Tea... showing 33,000 pins spread across the United States." The maps were hosted on Google Maps. (Notified by the BBC, Google deleted the maps, saying they violated their harassment policies.)

"Since the breach, more than 10 women have filed class actions against the company which owns Tea," the article points out, noting that leaked content is also spreading around social media:

Since the breach, the BBC has found websites, apps and even a "game" featuring the leaked data... The "game" puts the selfies submitted by women head-to-head, instructing users to click on the one they prefer, with leaderboards of the "top 50" and "bottom 50"... [And one researcher calculates more than 12,000 posts on 4Chan referenced the Tea app over the three weeks after the leak.]

It is unsurprising that the leak was exploited. The app had drawn criticism ever since it had grown in popularity. Defamation, with the spread of unproven allegations, and doxxing, when someone's identifying information is published without their consent, were real possibilities. Men's groups had wanted to take the app down — and when they found the data breach, they saw it as a chance for retribution.

They weren't the only ones with a gripe against Tea. Back in 2023 the fiance of Tea's CEO founder approached the administrator of a collection of Facebook groups called "Are We Dating the Same Guy?" to see if she'd be the "face" of the Tea app, reports 404 Media. But they add that after Tea failed to recruit her, Tea "shifted tactics" to raid her Facebook groups instead:
Tea paid influencers to undermine Are We Dating the Same Guy and created competing Facebook groups with nearly identical names. 404 Media also identified a number of seemingly hijacked Facebook accounts that spammed the real Are We Dating The Same Guy groups with links to Tea app.
Reviews for the Tea app show several women later thought the app was affiliated with their trusted Facebook groups, the reporter said this week on a 404 Media podcast.
And they add that founder Sean Cook took over the "Tara" personna that his fiance has used for technical support. "So he's on the app pretend to be a woman, talking to other women who are on the app in order to weed out men who are being deceptive..."
Thanks to Slashdot reader samleecole for sharing the article.

[ Read more of this story ]( https://tech.slashdot.org/story/25/08/24/2227258/after-tea-leak-33000-womens-addresses-were-purportedly-mapped-on-google-maps?utm_source=atom1.0moreanon&utm_medium=feed ) at Slashdot.

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#  A Universal Rhythm Guides How We Speak: Global Analysis Reveals 1.6-second Units
robot (spnet, 1) → All  –  21:22:01 2025-08-24

"The truly universal properties of languages are not independent of our physiology and cognition," argues the co-author of a new study. Instead he says their research "strengthens the idea that intonation units are a universal feature of language."

Phys.org explains:

Have you ever noticed that a natural conversation flows like a dance — pauses, emphases, and turns arriving just in time? A new study has discovered that this isn't just intuition; there is a biological rhythm embedded in our speech...

According to the study, led by Dr. Maya Inbar, alongside Professors Eitan Grossman and Ayelet N. Landau, human speech across the world pulses to the beat of what are called intonation units, short prosodic phrases that occur at a consistent rate of one every 1.6 seconds. The research analyzed over 650 recordings in 48 languages spanning every continent and 27 language families. Using a novel algorithm, the team was able to automatically identify intonation units in spontaneous speech, revealing that regardless of the language spoken, from English and Russian to endangered languages in remote regions, people naturally break their speech into these rhythmic chunks. "These findings suggest that the way we pace our speech isn't just a cultural artifact, it's deeply rooted in human cognition and biology," says Dr. Inbar.

"We also show that the rhythm of intonation units is unrelated to faster rhythms in speech, such as the rhythm of syllables, and thus likely serves a different cognitive role...." Most intriguingly, the low-frequency rhythm they follow mirrors patterns in brain activity linked to memory, attention, and volitional action, illuminating the profound connection between how we speak and how we think.

The work is published in the journal Proceedings of the National Academy of Sciences.

[ Read more of this story ]( https://science.slashdot.org/story/25/08/24/1920233/a-universal-rhythm-guides-how-we-speak-global-analysis-reveals-16-second-units?utm_source=atom1.0moreanon&utm_medium=feed ) at Slashdot.
#  30 Years of Satellite Data Confirm Predictions from Early Models of Sea Level Rise
robot (spnet, 1) → All  –  20:22:01 2025-08-24

"The ultimate test of climate projections is to compare them with what has played out..." says earth sciences professor Torbjörn Törnqvist, lead author on a new study published in the open-access journal Earth's Future (published by the American Geophysical Union).

But after "decades of observations," he says his researchers "were quite amazed how good those early projections were, especially when you think about how crude the models were back then, compared to what is available now."

"For anyone who questions the role of humans in changing our climate, here is some of the best proof that we have understood for decades what is really happening, and that we can make credible projections...."

A new era of monitoring global sea-level change took off when satellites were launched in the early 1990s to measure the height of the ocean surface. This showed that the rate of global sea-level rise since that time has averaged about one eighth of an inch per year. Only more recently, it became possible to detect that the rate of global sea-level rise is accelerating. When NASA researchers demonstrated in October 2024 that the rate has doubled during this 30-year period, the time was right to compare this finding with projections that were made during the mid-1990s, independent of the satellite measurements.

In 1996, the Intergovernmental Panel on Climate Change published an assessment report soon after the satellite-based sea-level measurements had started. It projected that the most likely amount of global sea-level rise over the next 30 years would be almost 8 centimeters (3 inches), remarkably close to the 9 centimeters that has occurred.

But it also underestimated the role of melting ice sheets by more than 2 centimeters (about 1 inch). At the time, little was known about the role of warming ocean waters and how that could destabilize marine sectors of the Antarctic Ice Sheet from below. Ice flow from the Greenland Ice Sheet into the ocean has also been faster than foreseen.

"The findings provide confidence in model-based climate projections," according to the paper. Again, its two key points:

The largest disparities between projections and observations were due to underestimated dynamic mass loss of ice sheets

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#  Flames, Smoke, Toxic Gas: The Danger of Battery Fires on Planes
robot (spnet, 1) → All  –  19:22:01 2025-08-24

"Delta Air Lines Flight 1334 was flying from Atlanta to Fort Lauderdale last month when smoke and flames started pouring out of a backpack," reports CNN. "The pilots declared an emergency and diverted to Fort Meyers where the 191 people onboard safely evacuated."

The culprit was a passenger's personal lithium-ion battery pack, which had been tucked away in the carry-on bag. At the FAA's William J. Hughes Technical Center for Advanced Aerospace in Atlantic City, New Jersey, fire safety engineers research and demonstrate just how bad it can be. "Lithium batteries can go into what's called thermal runaway," Fire Safety Branch Manager Robert Ochs, explained. "All of a sudden, it'll start to short circuit ... It will get warmer and warmer and warmer until the structure of the battery itself fails. At that point, it can eject molten electrolyte and flames and smoke and toxic gas...."

These thermal runaways are difficult to fight. The FAA recommends flight attendants first use a halon fire extinguisher, which is standard equipment on planes, but that alone may not be enough. In the test performed for CNN, the flames sprung back up in just moments... "Adding the water, as much water from the galley cart, non-alcoholic liquids, everything that they can get to just start pouring on that device." The problems are not new, but more batteries are being carried onto planes than ever before. Safety organization UL Standards and Engagement says today an average passenger flies with four devices powered by lithium-ion batteries. "The incidents of fire are rare, but they are increasing. We're seeing as many as two per week, either on planes or within airports," Jeff Marootian, the president and CEO of the organization, told CNN...

[T]he latest federal data shows external battery packs are the top cause of incidents, and as a result the FAA has banned them from checked baggage where they are harder to extinguish. But despite all of the warnings, UL Standards and Engagement says two in five passengers still say they check them.

[ Read more of this story ]( https://hardware.slashdot.org/story/25/08/24/1653202/flames-smoke-toxic-gas-the-danger-of-battery-fires-on-planes?utm_source=atom1.0moreanon&utm_medium=feed ) at Slashdot.
#  America's Secretive X-37B Space Plane Will Test a Quantum Alternative to GPS for the US Space Force
robot (spnet, 1) → All  –  18:22:01 2025-08-24

The mysterious X-37B space-plane — the U.S. military's orbital test vehicle — "serves partly as a platform for cutting-edge experiments," writes Space.com

And "one of these experiments is a potential alternative to GPS that makes use of quantum science as a tool for navigation: a quantum inertial sensor."

This technology could revolutionize how spacecraft, airplanes, ships and submarines navigate in environments where GPS is unavailable or compromised. In space, especially beyond Earth's orbit, GPS signals become unreliable or simply vanish. The same applies underwater, where submarines cannot access GPS at all. And even on Earth, GPS signals can be jammed (blocked), spoofed (making a GPS receiver think it is in a different location) or disabled — for instance, during a conflict... Traditional inertial navigation systems, which use accelerometers and gyroscopes to measure a vehicle's acceleration and rotation, do provide independent navigation, as they can estimate position by tracking how the vehicle moves over time... Eventually though, without visual cues, small errors will accumulate and you will entirely lose your positioning...

At very low temperatures, atoms obey the rules of quantum mechanics: they behave like waves and can exist in multiple states simultaneously — two properties that lie at the heart of quantum inertial sensors. The quantum inertial sensor aboard the X-37B uses a technique called atom interferometry, where atoms are cooled to the temperature of near absolute zero, so they behave like waves. Using fine-tuned lasers, each atom is split into what's called a superposition state, similar to Schrödinger's cat, so that it simultaneously travels along two paths, which are then recombined.
Since the atom behaves like a wave in quantum mechanics, these two paths interfere with each other, creating a pattern similar to overlapping ripples on water. Encoded in this pattern is detailed information about how the atom's environment has affected its journey. In particular, the tiniest shifts in motion, like sensor rotations or accelerations, leave detectable marks on these atomic "waves". Compared to classical inertial navigation systems, quantum sensors offer orders of magnitude greater sensitivity. Because atoms are identical and do not change, unlike mechanical components or electronics, they are far less prone to drift or bias. The result is long duration and high accuracy navigation without the need for external references.
The upcoming X-37B mission will be the first time this level of quantum inertial navigation is tested in space.
The article points out that a quantum navigation system could be crucial "for future space exploration, such as to the Moon, Mars or even deep space," where autonomy is key and when signals from Earth are unavailable.

"While quantum computing and quantum communication often steal headlines, systems like quantum clocks and quantum sensors are likely to be the first to see widespread use."

[ Read more of this story ]( https://science.slashdot.org/story/25/08/24/025222/americas-secretive-x-37b-space-plane-will-test-a-quantum-alternative-to-gps-for-the-us-space-force?utm_source=atom1.0moreanon&utm_medium=feed ) at Slashdot.
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